Research Studies

Large trials deliver results based on averages, not individuals. The N-of-1 model is a plucky—but labor-intensive—way to right the system.

Proton therapy has been a cutting-edge cancer therapy for decades. Can researchers at last zero in on its best applications?

Policymakers call for algorithms in health care to become more transparent. But at what cost?

New research looks into young people’s anxiety around environmental collapse.

What if drugs were released to the public earlier, then graded on their performance in the real world?

Troves of data are gathered during clinical trials, but most of it stays locked away. Could freeing it lead to new cures?

Peter L. Slavin & Thomas J. Lynch Jr. discuss the growing “open data” movement and its implications for scientific research

A funding shift may encourage more fundamental brain research.

Readers weigh in on the challenges of medical literacy and issues with replicating research.

It’s disappointing when seemingly groundbreaking studied can’t be repeated. But it’s happening a lot.

Peter L. Slavin and David F. Torchiana on the value of reproducing research.

Top Stories

Genomic analysis details how SARS-CoV-2 spread through Boston.

They represent a small minority of victims. But their illness could hold valuable lessons about how COVID-19 works—and how to stop it.

A pristine record of toxic exposures and psychological trauma rests in a child’s mouth—if only it can be decoded.

Selected Reads

For decades, a tiny encampment of researchers has held that statin treatment is a hoax. In a time when contrarian views roar to life on social media, how can medicine keep minority opinions from doing irreparable harm?

Two years in deep space will subject the body to unprecedented stresses. Scientists are probing the secrets to survival.

A freak explosion tore through the quiet Nova Scotian city, prompting one of the most dramatic medical responses in history.