Since 1923, Case Records of the Massachusetts General Hospital, a staple of The New England Journal of Medicine, has taught generations of students and physicians how to diagnose and treat baffling conditions. Also in this issue: The pandemic has ruptured relationships between the public and the medical world—and now several initiatives are trying to restore lost trust. Plus, new help for patients with functional neurological disorder, whose seizures and other symptoms are no longer dismissed as “all in their head.”