Even as COVID-19 continued to push other medical matters aside, this issue looked ahead to what the post-pandemic future might hold. Essays from 10 doctors, nurses, policymakers and others with a crucial stake in that future discuss how the pandemic, alongside a racial reckoning and a political shift, will change how and where care is delivered, by whom and how it is received. Plus, lessons from COVID responses in Denmark and Rwanda and the persistent danger of cholesterol deniers.