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The Coming of the Gene Switch

The concept of circuitry, borrowed from computer technology, could make the next generation of gene therapies more flexible and powerful.

Gene therapy takes many forms, but some of the most promising involve taking cells from the body and altering them so that they can perform new tasks. One example is chimeric antigen receptor T-cell therapy (CAR T), the first gene therapy to get approval from the Food and Drug Administration. CAR T reprograms immune cells called T cells and improves their...

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